Frequently Asked Questions

Magnesium Chloride Injection

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Minerals and electrolytes

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Magnesium Chloride Injection Description

Magnesium Chloride Injection is a sterile solution of Magnesium Chloride Hexahydrate in Water for Injection q.s. Each mL contains Magnesium Chloride Hexahydrate 200 mg, Sodium Chloride 9 mg, Benzyl Alcohol 1% as a preservative, Water for Injection, q.s. pH adjusted with Hydrochloric Acid and/or Sodium Hydroxide. Total osmolarity equivalent to 2.951 mOsm/mL.

Contains 1.97 mEq of Mg++ and Cl- per mL.

The structural formula is MgCl2•6H2O


Magnesium is the second most plentiful cation within cellular fluids. It is an important activator of many enzyme systems and deficits are accompanied by a variety of functional disturbances.

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As an electrolyte replenisher in magnesium deficiencies.


Magnesium Chloride Injection should not be administered if there is renal impairment, marked myocardial disease or to comatose patients.


Do not use if a precipitate is present.


The usual precautions for parenteral administration should be observed. Administer with caution if flushing and sweating occurs. A preparation of a calcium salt should be readily available for intravenous injection to counteract potential serious signs of magnesium intoxication. As long as deep tendon reflexes are active it is probable that the patient will not develop respiratory paralysis. Respiration and blood pressure should be carefully observed during and after administration of Magnesium Chloride Injection.


Teratogenic Effects

Pregnancy Category C

Animal reproduction studies have not been conducted with magnesium chloride. It is also not known whether magnesium chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Magnesium Chloride should be given to a pregnant woman only if clearly needed.

Adverse Reactions

Flushing, sweating, sharply lowered blood pressure,hypothermia, stupor and ultimately respiratory depression.

Magnesium Chloride Injection Dosage and Administration

For intravenous infusion: 4 grams in 250 mL of 5%Dextrose Injection, at a rate not exceeding 3 mL per minute. Serum magnesium levels should serve as a guide to continued dosage.


1 to 40 grams daily.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

How is Magnesium Chloride Injection Supplied

Magnesium Chloride Injection 200 mg/mL (20% w/v).

NDC 67457-134-50
50 mL Multiple-Dose Vial. Individually boxed.

Store at 20° to 25°C (68° to 77°F). [See USP Controlled
Room Temperature.]

Manufactured for:
Mylan Institutional LLC
Rockford, IL 61103

Manufactured by:
Mylan Institutional
Galway, Ireland




NDC 67457-134-50     50 mL


200 mg/mL
(20% w/v)

2.951 mOsm/mL

For Intravenous Use After

Rx only Multiple-Dose Vial

Manufactured for:
Mylan Institutional LLC
Rockford, IL 61103 U.S.A.

Manufactured by:
Mylan Institutional
Galway, Ireland


Each mL contains: Magnesium
Chloride Hexahydrate 200 mg,
Sodium Chloride 9 mg, Benzyl
Alcohol 1% as a preservative,
Water for Injection q.s. pH adjusted
with Hydrochloric Acid and/or
Sodium Hydroxide.

Total osmolarity equivalent to
2.951 mOsm/mL.

Contains 1.97 mEq of Mg++ and CI¯
per mL.


Store at 20° to 25°C (68° to 77°F).
[See USP Controlled Room

Usual Dosage: See accompanying
prescribing information.

Magnesium Chloride Injection
Product Information
Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:67457-134
Route of Administration INTRAVENOUS DEA Schedule     
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
Inactive Ingredients
Ingredient Name Strength
BENZYL ALCOHOL 10 mg  in 1 mL
# Item Code Package Description
1 NDC:67457-134-50 1 VIAL, MULTI-DOSE in 1 CARTON
1 50 mL in 1 VIAL, MULTI-DOSE
Marketing Information
Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
Unapproved drug other 03/14/2013
Labeler - Mylan Institutional LLC (790384502)
Revised: 03/2013
Mylan Institutional LLC

Not all side effects for magnesium chloride may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to magnesium chloride: sustained-release tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Seek medical attention right away if any of these SEVERE side effects occur while taking magnesium chloride:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); nausea; slow reflexes.

For Healthcare Professionals

Applies to magnesium chloride: compounding powder, injectable solution, oral tablet extended release


Other side effects have resulted from toxicity (hypermagnesemia). Mild hypermagnesemia is generally well-tolerated. Moderate or severe hypermagnesemia primarily affects the nervous and cardiovascular systems. The effects of hypermagnesemia may be worsened by the presence of hypocalcemia, especially in patients with uremia.[Ref]


Gastrointestinal side effects have included diarrhea. Magnesium toxicity has been associated with nausea (magnesium levels of 4 to 5 mEq/L) and rare cases of paralytic ileus (magnesium levels greater than 5 mEq/L).[Ref]

Nervous system

Nervous system side effects have resulted from the suppression of neuromuscular transmission in the CNS and at the neuromuscular junction by magnesium (antagonized by calcium). The degree of severity of these side effects has been dependent on the serum magnesium level. Clinically, if serum magnesium (Mg) levels increase to 4 to 7 mEq/L, there may be a decrease in tendon reflexes, muscle weakness and/or mental confusion/sedation. At levels of 7 to 10 mEq/L the respiratory rate slows and the blood pressure falls. At levels of 10 to 15 mEq/L there is usually profound mental depression, areflexia, coma and respiratory paralysis. Magnesium also has a curare-like effect at the neuromuscular junction at serum levels above 10 mEq/L. Death is not uncommon when serum magnesium levels rise to 15 mEq/L.[Ref]


The cardiovascular consequences of hypermagnesemia are due to peripheral vasodilation. Hypotension may be observed when serum magnesium levels rise to 7 to 10 mEq/L, becoming severe when serum magnesium levels rise above 10 mEq/L. Magnesium can also depress myocardial conductivity at levels greater than 10 mEq/L. This can result in bradyarrhythmias. While some patients are inexplicably able to tolerate extraordinary magnesium levels, there is a significant risk of asystole when levels rise to 25 mEq/L. The risk of cardiotoxicity from hypermagnesemia is increased in the presence of hypocalcemia, hyperkalemia, acidosis, digitalis therapy, and renal insufficiency.[Ref]

Cardiovascular side effects have included hypotension, depressed myocardial conductivity and asystole.[Ref]


Acute hypermagnesemia may cause hypocalcemia due to suppression of the release of parathyroid hormone (PTH) and competition for renal tubular reabsorption between calcium (Ca) and magnesium. The latter can lead to decreased Ca reabsorption and hypercalciuria, which aggravates the hypocalcemia produced by decreased release of PTH.[Ref]

Metabolic side effects have included hypocalcemia.[Ref]


Magnesium chloride is generally well tolerated.[Ref]


1. Fung MC, Weintraub M, Bowen DL "Hypermagnesemia: elderly over-the-counter drug users at risk." Arch Fam Med 4 (1995): 718-23

2. "Product Information. Slow-Mag (magnesium chloride)." Searle, Skokie, IL.

3. Golzarian J, Scott HW, Richards WO "Hypermagnesemia-induced paralytic ileus." Dig Dis Sci 39 (1994): 1138-42

4. Bashir Y, Sneddon JF, Staunton HA, Haywood GA, Simpson IA, McKenna WJ, Camm AJ "Effects of long-term oral magnesium chloride replacement in congestive heart failure secondary to coronary artery disease." Am J Cardiol 72 (1993): 1156-62

5. Ricci JM, Hariharan S, Helfgott A, Reed K, O'Sullivan MJ "Oral tocolysis with magnesium chloride: a randomized controlled prospective clinical trial." Am J Obstet Gynecol 165 (1991): 603-10

6. Ridgway LE 3d, Muise K, Wright JW, Patterson RM, Newton ER "A prospective randomized comparison of oral terbutaline and magnesium oxide for the maintenance of tocolysis." Am J Obstet Gynecol 163 (1990): 879-82

7. Wilson J, Braunwald E, Isselbacher K, Petersdorf R, Martin J, Fauci A, Root R "Harrison's Principles of Internal Medicine, 12th Edition." McGraw-Hill, Inc., Health Professions Division, New York 1 (1991): 1938

8. Jenny DB, Goris GB, Urwiller RD, Brian BA "Hypermagnesemia following irrigation of renal pelvis. Cause of respiratory depression." JAMA 240 (1978): 1378-9

9. Alison LH, Bulugahapitiya D "Laxative induced magnesium poisoning in a 6 week old infant." BMJ 300 (1990): 125

10. Schrier RW, Gottschalk CW, Eds. "Diseases of the Kidney, 5th Edition." Boston, MA: Little, Brown and Company 1-3 (1993): 183-2653

11. Feldstedt M, Boesgaard S, Bouchelouche P, Svenningsen A, Brooks L, Lech Y, Aldershvile J, Skagen K, Godtfredsen J "Magnesium substitution in acute ischaemic heart syndromes." Eur Heart J 12 (1991): 1215-8

12. Kelepouris E, Kasama R, Agus ZS "Effects of intracellular magnesium on calcium, potassium and chloride channels." Miner Electrolyte Metab 19 (1993): 277-81

13. Neumann L, Jensen BG "Osteomalacia from Al and Mg antacids. Report of a case of bilateral hip fracture." Acta Orthop Scand 60 (1989): 361-2

14. Cumming WA, Thomas VJ "Hypermagnesemia: a cause of abnormal metaphyses in the neonate." AJR Am J Roentgenol 152 (1989): 1071-2

15. Lembcke B, Fuchs C "Magnesium load induced by ingestion of magnesium-containing antacids." Contrib Nephrol 38 (1984): 185-94

More about magnesium chloride

  • Side Effects
  • During Pregnancy
  • Dosage Information
  • Drug Interactions
  • Support Group
  • 0 Reviews - Add your own review/rating

Consumer resources

  • Magnesium chloride sustained-release tablets
  • Magnesium chloride
  • Other brands: Mag-SR

Professional resources

  • Magnesium Chloride Injection (FDA)
  • Magnesium Chloride (Wolters Kluwer)

Related treatment guides

  • Heart Attack
  • Hypomagnesemia

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