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Magnesium Chloride Injection is a sterile solution of Magnesium Chloride Hexahydrate in Water for Injection q.s. Each mL contains Magnesium Chloride Hexahydrate 200 mg, Sodium Chloride 9 mg, Benzyl Alcohol 1% as a preservative, Water for Injection, q.s. pH adjusted with Hydrochloric Acid and/or Sodium Hydroxide. Total osmolarity equivalent to 2.951 mOsm/mL.
Contains 1.97 mEq of Mg++ and Cl- per mL.
The structural formula is MgCl2•6H2O
Magnesium is the second most plentiful cation within cellular fluids. It is an important activator of many enzyme systems and deficits are accompanied by a variety of functional disturbances.
As an electrolyte replenisher in magnesium deficiencies.
Magnesium Chloride Injection should not be administered if there is renal impairment, marked myocardial disease or to comatose patients.
Do not use if a precipitate is present.
The usual precautions for parenteral administration should be observed. Administer with caution if flushing and sweating occurs. A preparation of a calcium salt should be readily available for intravenous injection to counteract potential serious signs of magnesium intoxication. As long as deep tendon reflexes are active it is probable that the patient will not develop respiratory paralysis. Respiration and blood pressure should be carefully observed during and after administration of Magnesium Chloride Injection.
Animal reproduction studies have not been conducted with magnesium chloride. It is also not known whether magnesium chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Magnesium Chloride should be given to a pregnant woman only if clearly needed.
Flushing, sweating, sharply lowered blood pressure,hypothermia, stupor and ultimately respiratory depression.
For intravenous infusion: 4 grams in 250 mL of 5%Dextrose Injection, at a rate not exceeding 3 mL per minute. Serum magnesium levels should serve as a guide to continued dosage.
1 to 40 grams daily.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
Magnesium Chloride Injection 200 mg/mL (20% w/v).
50 mL Multiple-Dose Vial. Individually boxed.
Store at 20° to 25°C (68° to 77°F). [See USP Controlled
Mylan Institutional LLC
Rockford, IL 61103
REVISED FEBRUARY 2013
PRINCIPAL DISPLAY PANEL - 200 mg/mL
NDC 67457-134-50 50 mL
For Intravenous Use After
Rx only Multiple-Dose Vial
Mylan Institutional LLC
Rockford, IL 61103 U.S.A.
Each mL contains: Magnesium
Chloride Hexahydrate 200 mg,
Sodium Chloride 9 mg, Benzyl
Alcohol 1% as a preservative,
Water for Injection q.s. pH adjusted
with Hydrochloric Acid and/or
Total osmolarity equivalent to
Contains 1.97 mEq of Mg++ and CI¯
WARNING: DO NOT USE IF A
PRECIPITATE IS PRESENT.
Store at 20° to 25°C (68° to 77°F).
[See USP Controlled Room
Usual Dosage: See accompanying
|MAGNESIUM CHLORIDE |
Magnesium Chloride Injection
|Labeler - Mylan Institutional LLC (790384502)|
Not all side effects for magnesium chloride may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
Applies to magnesium chloride: sustained-release tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking magnesium chloride:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); nausea; slow reflexes.
Applies to magnesium chloride: compounding powder, injectable solution, oral tablet extended release
Other side effects have resulted from toxicity (hypermagnesemia). Mild hypermagnesemia is generally well-tolerated. Moderate or severe hypermagnesemia primarily affects the nervous and cardiovascular systems. The effects of hypermagnesemia may be worsened by the presence of hypocalcemia, especially in patients with uremia.[Ref]
Gastrointestinal side effects have included diarrhea. Magnesium toxicity has been associated with nausea (magnesium levels of 4 to 5 mEq/L) and rare cases of paralytic ileus (magnesium levels greater than 5 mEq/L).[Ref]
Nervous system side effects have resulted from the suppression of neuromuscular transmission in the CNS and at the neuromuscular junction by magnesium (antagonized by calcium). The degree of severity of these side effects has been dependent on the serum magnesium level. Clinically, if serum magnesium (Mg) levels increase to 4 to 7 mEq/L, there may be a decrease in tendon reflexes, muscle weakness and/or mental confusion/sedation. At levels of 7 to 10 mEq/L the respiratory rate slows and the blood pressure falls. At levels of 10 to 15 mEq/L there is usually profound mental depression, areflexia, coma and respiratory paralysis. Magnesium also has a curare-like effect at the neuromuscular junction at serum levels above 10 mEq/L. Death is not uncommon when serum magnesium levels rise to 15 mEq/L.[Ref]
The cardiovascular consequences of hypermagnesemia are due to peripheral vasodilation. Hypotension may be observed when serum magnesium levels rise to 7 to 10 mEq/L, becoming severe when serum magnesium levels rise above 10 mEq/L. Magnesium can also depress myocardial conductivity at levels greater than 10 mEq/L. This can result in bradyarrhythmias. While some patients are inexplicably able to tolerate extraordinary magnesium levels, there is a significant risk of asystole when levels rise to 25 mEq/L. The risk of cardiotoxicity from hypermagnesemia is increased in the presence of hypocalcemia, hyperkalemia, acidosis, digitalis therapy, and renal insufficiency.[Ref]
Cardiovascular side effects have included hypotension, depressed myocardial conductivity and asystole.[Ref]
Acute hypermagnesemia may cause hypocalcemia due to suppression of the release of parathyroid hormone (PTH) and competition for renal tubular reabsorption between calcium (Ca) and magnesium. The latter can lead to decreased Ca reabsorption and hypercalciuria, which aggravates the hypocalcemia produced by decreased release of PTH.[Ref]
Metabolic side effects have included hypocalcemia.[Ref]
Magnesium chloride is generally well tolerated.[Ref]
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9. Alison LH, Bulugahapitiya D "Laxative induced magnesium poisoning in a 6 week old infant." BMJ 300 (1990): 125
10. Schrier RW, Gottschalk CW, Eds. "Diseases of the Kidney, 5th Edition." Boston, MA: Little, Brown and Company 1-3 (1993): 183-2653
11. Feldstedt M, Boesgaard S, Bouchelouche P, Svenningsen A, Brooks L, Lech Y, Aldershvile J, Skagen K, Godtfredsen J "Magnesium substitution in acute ischaemic heart syndromes." Eur Heart J 12 (1991): 1215-8
12. Kelepouris E, Kasama R, Agus ZS "Effects of intracellular magnesium on calcium, potassium and chloride channels." Miner Electrolyte Metab 19 (1993): 277-81
13. Neumann L, Jensen BG "Osteomalacia from Al and Mg antacids. Report of a case of bilateral hip fracture." Acta Orthop Scand 60 (1989): 361-2
14. Cumming WA, Thomas VJ "Hypermagnesemia: a cause of abnormal metaphyses in the neonate." AJR Am J Roentgenol 152 (1989): 1071-2
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