Frequently Asked Questions

magnesium chloride sustained-release tablets

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Examples include Mag-SR and Slow-Mag

Minerals and electrolytes


Magnesium chloride sustained-release tablets is used for:

Treating low magnesium levels or maintaining the proper amount of magnesium in the body. It also may be used for other conditions as determined by your doctor.

Magnesium chloride sustained-release tablets is an essential mineral. It works by adding magnesium to your body if your magnesium levels are low.

Do NOT use magnesium chloride sustained-release tablets if:

  • you are allergic to any ingredient in magnesium chloride sustained-release tablets

Contact your doctor or health care provider right away if any of these apply to you.

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Before using magnesium chloride sustained-release tablets:

Some medical conditions may interact with magnesium chloride sustained-release tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have appendicitis, diarrhea, a blockage of your intestines, heart problems, or kidney problems

Some MEDICINES MAY INTERACT with magnesium chloride sustained-release tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin) because the risk of their side effects may be increased by magnesium chloride sustained-release tablets
  • Bisphosphonates (eg, risedronate), digoxin, penicillamine, quinolone antibiotics (eg, ciprofloxacin), or tetracyclines (eg, doxycycline) because their effectiveness may be decreased by magnesium chloride sustained-release tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if magnesium chloride sustained-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use magnesium chloride sustained-release tablets:

Use magnesium chloride sustained-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take magnesium chloride sustained-release tablets by mouth with food.
  • If you miss a dose of magnesium chloride sustained-release tablets and are using it regularly, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use magnesium chloride sustained-release tablets.

Important safety information:

  • Tell your doctor or dentist that you take magnesium chloride sustained-release tablets before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including magnesium levels, may be performed while you use magnesium chloride sustained-release tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Magnesium chloride sustained-release tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using magnesium chloride sustained-release tablets while you are pregnant. It is not known if magnesium chloride sustained-release tablets is found in breast milk. If you are or will be breast-feeding, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of magnesium chloride sustained-release tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); nausea; slow reflexes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; dizziness; flushing; loss of consciousness; muscle weakness; severe drowsiness; slow heartbeat.

Proper storage of magnesium chloride sustained-release tablets:

Store magnesium chloride sustained-release tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep magnesium chloride sustained-release tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about magnesium chloride sustained-release tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Magnesium chloride sustained-release tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take magnesium chloride sustained-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about magnesium chloride sustained-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to magnesium chloride sustained-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using magnesium chloride sustained-release tablets.

Issue Date: February 4, 2015
Database Edition 15.1.1.002
Copyright © 2015 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Not all side effects for magnesium chloride may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to magnesium chloride: sustained-release tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea.

Seek medical attention right away if any of these SEVERE side effects occur while taking magnesium chloride:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); nausea; slow reflexes.

For Healthcare Professionals

Applies to magnesium chloride: compounding powder, injectable solution, oral tablet extended release

Other

Other side effects have resulted from toxicity (hypermagnesemia). Mild hypermagnesemia is generally well-tolerated. Moderate or severe hypermagnesemia primarily affects the nervous and cardiovascular systems. The effects of hypermagnesemia may be worsened by the presence of hypocalcemia, especially in patients with uremia.[Ref]

Gastrointestinal

Gastrointestinal side effects have included diarrhea. Magnesium toxicity has been associated with nausea (magnesium levels of 4 to 5 mEq/L) and rare cases of paralytic ileus (magnesium levels greater than 5 mEq/L).[Ref]

Nervous system

Nervous system side effects have resulted from the suppression of neuromuscular transmission in the CNS and at the neuromuscular junction by magnesium (antagonized by calcium). The degree of severity of these side effects has been dependent on the serum magnesium level. Clinically, if serum magnesium (Mg) levels increase to 4 to 7 mEq/L, there may be a decrease in tendon reflexes, muscle weakness and/or mental confusion/sedation. At levels of 7 to 10 mEq/L the respiratory rate slows and the blood pressure falls. At levels of 10 to 15 mEq/L there is usually profound mental depression, areflexia, coma and respiratory paralysis. Magnesium also has a curare-like effect at the neuromuscular junction at serum levels above 10 mEq/L. Death is not uncommon when serum magnesium levels rise to 15 mEq/L.[Ref]

Cardiovascular

The cardiovascular consequences of hypermagnesemia are due to peripheral vasodilation. Hypotension may be observed when serum magnesium levels rise to 7 to 10 mEq/L, becoming severe when serum magnesium levels rise above 10 mEq/L. Magnesium can also depress myocardial conductivity at levels greater than 10 mEq/L. This can result in bradyarrhythmias. While some patients are inexplicably able to tolerate extraordinary magnesium levels, there is a significant risk of asystole when levels rise to 25 mEq/L. The risk of cardiotoxicity from hypermagnesemia is increased in the presence of hypocalcemia, hyperkalemia, acidosis, digitalis therapy, and renal insufficiency.[Ref]

Cardiovascular side effects have included hypotension, depressed myocardial conductivity and asystole.[Ref]

Metabolic

Acute hypermagnesemia may cause hypocalcemia due to suppression of the release of parathyroid hormone (PTH) and competition for renal tubular reabsorption between calcium (Ca) and magnesium. The latter can lead to decreased Ca reabsorption and hypercalciuria, which aggravates the hypocalcemia produced by decreased release of PTH.[Ref]

Metabolic side effects have included hypocalcemia.[Ref]

General

Magnesium chloride is generally well tolerated.[Ref]

References

1. Fung MC, Weintraub M, Bowen DL "Hypermagnesemia: elderly over-the-counter drug users at risk." Arch Fam Med 4 (1995): 718-23

2. "Product Information. Slow-Mag (magnesium chloride)." Searle, Skokie, IL.

3. Golzarian J, Scott HW, Richards WO "Hypermagnesemia-induced paralytic ileus." Dig Dis Sci 39 (1994): 1138-42

4. Bashir Y, Sneddon JF, Staunton HA, Haywood GA, Simpson IA, McKenna WJ, Camm AJ "Effects of long-term oral magnesium chloride replacement in congestive heart failure secondary to coronary artery disease." Am J Cardiol 72 (1993): 1156-62

5. Ricci JM, Hariharan S, Helfgott A, Reed K, O'Sullivan MJ "Oral tocolysis with magnesium chloride: a randomized controlled prospective clinical trial." Am J Obstet Gynecol 165 (1991): 603-10

6. Ridgway LE 3d, Muise K, Wright JW, Patterson RM, Newton ER "A prospective randomized comparison of oral terbutaline and magnesium oxide for the maintenance of tocolysis." Am J Obstet Gynecol 163 (1990): 879-82

7. Wilson J, Braunwald E, Isselbacher K, Petersdorf R, Martin J, Fauci A, Root R "Harrison's Principles of Internal Medicine, 12th Edition." McGraw-Hill, Inc., Health Professions Division, New York 1 (1991): 1938

8. Jenny DB, Goris GB, Urwiller RD, Brian BA "Hypermagnesemia following irrigation of renal pelvis. Cause of respiratory depression." JAMA 240 (1978): 1378-9

9. Alison LH, Bulugahapitiya D "Laxative induced magnesium poisoning in a 6 week old infant." BMJ 300 (1990): 125

10. Schrier RW, Gottschalk CW, Eds. "Diseases of the Kidney, 5th Edition." Boston, MA: Little, Brown and Company 1-3 (1993): 183-2653

11. Feldstedt M, Boesgaard S, Bouchelouche P, Svenningsen A, Brooks L, Lech Y, Aldershvile J, Skagen K, Godtfredsen J "Magnesium substitution in acute ischaemic heart syndromes." Eur Heart J 12 (1991): 1215-8

12. Kelepouris E, Kasama R, Agus ZS "Effects of intracellular magnesium on calcium, potassium and chloride channels." Miner Electrolyte Metab 19 (1993): 277-81

13. Neumann L, Jensen BG "Osteomalacia from Al and Mg antacids. Report of a case of bilateral hip fracture." Acta Orthop Scand 60 (1989): 361-2

14. Cumming WA, Thomas VJ "Hypermagnesemia: a cause of abnormal metaphyses in the neonate." AJR Am J Roentgenol 152 (1989): 1071-2

15. Lembcke B, Fuchs C "Magnesium load induced by ingestion of magnesium-containing antacids." Contrib Nephrol 38 (1984): 185-94

More about magnesium chloride

  • Side Effects
  • During Pregnancy
  • Dosage Information
  • Drug Interactions
  • Support Group
  • 0 Reviews - Add your own review/rating

Consumer resources

  • Magnesium chloride sustained-release tablets
  • Magnesium chloride
  • Other brands: Mag-SR

Professional resources

  • Magnesium Chloride Injection (FDA)
  • Magnesium Chloride (Wolters Kluwer)

Related treatment guides

  • Heart Attack
  • Hypomagnesemia

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