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Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.
Abiraterone acetate is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with abiraterone acetate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with abiraterone acetate. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if abiraterone acetate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use abiraterone acetate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use abiraterone acetate.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bone pain; chest pain or discomfort; confusion; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; leg pain; muscle pain, weakness, or cramping; severe or persistent headache, dizziness, or light-headedness; shortness of breath; sudden or unexplained weight gain; swelling of the hands, ankles, legs, or feet; symptoms of liver problems (eg, dark urine; loss of appetite; pale stools; unusual nausea, stomach pain, or tiredness; yellowing of the skin or eyes); unusual bruising; unusual tiredness or weakness; urination problems (eg, difficult, increased, or painful urination).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of abiraterone acetate:
Store abiraterone acetate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep abiraterone acetate out of the reach of children and away from pets.
This information should not be used to decide whether or not to take abiraterone acetate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about abiraterone acetate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to abiraterone acetate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using abiraterone acetate.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
Not all side effects for abiraterone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
Applies to abiraterone: oral tablet
In addition to its needed effects, some unwanted effects may be caused by abiraterone. In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking abiraterone:More common
Some of the side effects that can occur with abiraterone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
Applies to abiraterone: oral tablet
In general, the most commonly reported side effects have included joint swelling or discomfort, hypokalemia, edema, muscle discomfort, hot flushes, diarrhea, urinary tract infection, cough, hypertension, arrhythmia, urinary frequency, nocturia, dyspepsia, and upper respiratory tract infection. The most common adverse effects which resulted in discontinuation of abiraterone have included increased transaminases (ALT, AST), urosepsis, and heart failure.[Ref]
Cardiovascular side effects have included hypertension, edema, hot flushes, arrhythmias, atrial and ventricular tachycardia, supraventricular tachycardia, atrial flutter, bradycardia, AV block, chest pain or discomfort, angina, left ventricular dysfunction, cardiogenic shock, cardiomegaly, cardiomyopathy, decreased ejection fraction, and heart failure.[Ref]
Endocrine side effects have included adrenocortical insufficiency.[Ref]
Gastrointestinal side effects have included diarrhea and dyspepsia.[Ref]
Genitourinary side effects have included urinary tract infection, urinary frequency, nocturia, and urosepsis.[Ref]
Hepatic side effects have included hepatotoxicity, increased AST, increased ALT, and increased bilirubin[Ref]
Metabolic side effects have included hypokalemia, fluid retention, and low serum phosphate.[Ref]
Musculoskeletal side effects have included joint swelling or discomfort, muscle discomfort, arthritis, arthralgia, muscle spasms, musculoskeletal pain or discomfort, myalgia and fractures.[Ref]
Respiratory side effects have included cough and upper respiratory tract infection.[Ref]
1. "Product Information. Zytiga (abiraterone)." Centocor Inc, Malvern, PA.
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