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Examples include Aralast NP and Zemaira
Miscellaneous respiratory agents
Treating emphysema caused by alpha-1 proteinase inhibitor deficiency (also known as alpha-1 antitrypsin deficiency).
Alpha-1 proteinase inhibitor (human) is an alpha-1 protease inhibitor. It works by blocking substances in the lungs that break down lung tissue and sometimes causes emphysema.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with alpha-1 proteinase inhibitor (human). Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with alpha-1 proteinase inhibitor (human). However, no specific interactions with alpha-1 proteinase inhibitor (human) are known at this time.
Ask your health care provider if alpha-1 proteinase inhibitor (human) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use alpha-1 proteinase inhibitor (human) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use alpha-1 proteinase inhibitor (human).
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dizziness; headache; muscle pain; nausea; pain, bruising, swelling, or redness at the injection site; runny nose.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; severe or persistent dizziness; shortness of breath or wheezing; swelling of the ankles or feet; symptoms of infection (eg, fever, chills, muscle aches, sore throat); tingling or numbness of the skin; weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of alpha-1 proteinase inhibitor (human):
Alpha-1 proteinase inhibitor (human) is handled and stored by a health care provider. You will not store it at home. Keep all medicines, as well as needles and syringes, out of the reach of children and away from pets.
This information should not be used to decide whether or not to take alpha-1 proteinase inhibitor (human) or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about alpha-1 proteinase inhibitor (human). It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to alpha-1 proteinase inhibitor (human). This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using alpha-1 proteinase inhibitor (human).
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
Not all side effects for alpha 1-proteinase inhibitor may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
Applies to alpha 1-proteinase inhibitor: intravenous powder for solution, intravenous solution
In addition to its needed effects, some unwanted effects may be caused by alpha 1-proteinase inhibitor. In the event that any of these side effects do occur, they may require medical attention.
If any of the following side effects occur while taking alpha 1-proteinase inhibitor, check with your doctor or nurse immediately:More common
Some of the side effects that can occur with alpha 1-proteinase inhibitor may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
Applies to alpha 1-proteinase inhibitor: intravenous powder for injection, intravenous solution
Respiratory side effects have included chest pain, pharyngitis, asthma, rhinitis, bronchitis, sinusitis, increased cough, upper and lower respiratory tract infections, dyspnea, chronic obstructive pulmonary disease (COPD) exacerbation, nasopharyngitis, pharyngolaryngeal pain, COPD, sore throat, bronchospasm, lung disorder, infective exacerbation of COPD, bilateral pulmonary infiltrates, and diffuse interstitial lung disease. Dyspnea has been reported during postmarketing experience.[Ref]
Nervous system side effects have included dizziness, headache, somnolence, dysgeusia, lethargy, lightheadedness, paresthesia, and migraine.[Ref]
Other side effects have included pain, back pain, viral infection, peripheral edema, chills, fever, chest pain, chest discomfort, influenza-like illness, pyrexia, delayed fever, influenza-like symptoms, allergic-like reactions, malaise, hot flush, asthenia, infection, and accidental injury. Chest pain, chills, and influenza-like illness have been reported during postmarketing experience.
Cardiovascular side effects have included vasodilation, hypertension, tachycardia, hypotension, and transient increase in blood pressure. Tachycardia, hypotension, and hypertension (including transient increases of blood pressure) have been reported during postmarketing experience.[Ref]
Hematologic side effects have included decreased platelet count, transient leukocytosis, dilutional anemia, ecchymosis, and hemorrhage.
Dermatologic side effects have included pruritus, rash, erythema marginatum, and urticaria. Rash has been reported during postmarketing experience.[Ref]
Gastrointestinal side effects have included bloating, nausea, abdominal pain, diarrhea, and dyspepsia.
Hepatic side effects have included elevations (greater than 2 times the upper limit of normal) in aminotransferases (ALT or AST), increased hepatic enzyme (unspecified), and cholangitis.[Ref]
Musculoskeletal side effects have included musculoskeletal discomfort, joint swelling, arthralgia, and myalgia.
Ocular side effects have included abnormal vision.[Ref]
Local side effects have included injection site pain, injection site hemorrhage, and injection site reaction.
Genitourinary side effects have included urinary tract infection.
Hypersensitivity side effects have included hypersensitivity during postmarketing experience.
1. "Product Information. Aralast (alpha 1-proteinase inhibitor)." Baxter I.V. Systems Division, Round Lake, IL.
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